DotNetNuke (DNN) can provide good performance if optimized properly. Quick settings like enabling caching and optimizing caching settings, minimizing large images and optimizing image sizes, reducing external script usage and reducing script size, enabling compression for text-based files, upgrading to the latest version of DotNetNuke to take advantage of performance improvements and bug fixes certainly leads better result but here are some detailed tips to optimize performance in DNN:

1. Caching: DNN provides caching functionality that can help improve website performance by reducing the amount of data that needs to be loaded each time a user accesses a page.

2. Minification and compression: DNN provides tools for minifying and compressing website assets such as CSS and JavaScript files, which can help reduce page load times.

3. Content Delivery Network (CDN) integration: DNN can be integrated with a CDN to cache website content and distribute it from servers around the world, improving website speed for users in different locations.

4. Optimize database performance: Database performance can have a significant impact on the performance of a DNN website. Optimize database performance by minimizing the number of queries and optimizing database indexes, minimizing table joins, and using stored procedures.

5. Image optimization: Optimizing images by reducing their file size and using responsive images can help improve website speed.

6. Third-party modules: Be careful when selecting and using third-party modules. Poorly designed or inefficient modules can negatively impact website performance.

7. Minimize HTTP requests: Minimize the number of HTTP requests by combining multiple scripts into a single file and reducing the number of images on a page.

8. Monitor server performance: Monitor server performance to identify bottlenecks or performance issues that could be impacting the performance of a DNN website.

9. Use a fast and reliable web hosting service: Using elastic resources and cloud hosting speeds up and improves the performance of DNN Pages. You can make quick adjustments to your resources for better performance.
10. Enable HTTP compression for text-based files to reduce their sizes and improve download speed and Apply IIS configuration options to improve IIS performance.

By following these tips and optimizing DNN properly, it is possible to achieve good performance and provide users with a fast and responsive website.